人永生化子宫内膜基质细胞系(HESC)

背景介绍/context：

Decidualization of the endometrium, mainly induced by progesterone, is a process of endometrial remodelling where the endometrial stromal cells differentiate into secretory decidual cells in preparation for pregnancy. Decidualized endometrial stromal cells are characterized by release of prolactin (PRL), RI-like growth factor binding protein-1 (IGFBP-1), tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1), and expression of basal lamina components such as laminin, collagen IV, and fibronectin. 

Immortalised Human Endometrial Stromal Cells (HESC) are unique in that 1) they display normal karyotype and 2) they respond to hormone stimulation and retain the morphological pattern and biochemical endpoints of decidualization after treatment of oestradiol and medroxyprogesterone, making this cell line a valuable tool in endometrium homeostasis and female reproductive studies.

子宫内膜蜕膜化是子宫内膜重构的一个过程，主要由孕酮引起，子宫内膜基质细胞分化为分泌蜕膜细胞，为妊娠做准备。蜕膜化的子宫内膜基质细胞的特征是泌乳素(PRL)、蛋白样生长因子结合蛋白-1 (IGFBP-1)、组织因子(TF)、纤溶酶原激活物抑制因子-1 (PAI-1)的释放，以及层粘连蛋白、IV型胶原和纤连蛋白等基础层结构成分的表达。

人永生化子宫内膜基质细胞(HESC)是独一无二的,1)他们显示正常核型和2)应对荷尔蒙刺激和保留的形态和生化模式端点decidualization甲羟孕酮和雌二醇治疗后,做这个细胞株子宫内膜内稳态和女性生殖研究中一个有价值的工具。

动物种别/Organism  人

组织来源 Tissue and Cell Type 子宫内膜

形态/Morphology 贴壁生长 

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