HK-1人鼻咽癌细胞系

HK-1 细胞（完整名称：NPC/HK-1）是一株人源鼻咽鳞癌细胞系，1979-1980 年由香港大学 Huang 等建系，取自 1 例 58 岁男性患者在放疗 17 年半后复发的鼻咽癌组织，是目前国际上使用最广泛的鼻咽癌体外模型之一 。

组织来源: 鼻咽部复发性高分化鳞癌

形态 ：上皮细胞样，单层贴壁生长

培养基配方：

90%RPMI-1640(MD0200)+10%胎牛血清(SD0200)+G/A (SD0038)

完全培养基：RPMI-1640完全培养基（货号：MD0201）

气相：空气，95%；二氧化碳，5%。 温度：37°C。

完全冻存液：免程序降温细胞冻存液（低血清）(SD0001)

声明：产品仅科研使用。

1.PubMed=6259064; DOI=10.1002/ijc.2910260202
Dolly Wai-Sen Huang Poon, John Hung-Chiu Ho, Yeuk-Foo Poon, Eng-Ching Chew, Daisy Saw, M. Lui, C.L. Li, L.S. Mak, S.H. Lai, Wai-Hon Lau;
Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of the nasopharynx.
Int. J. Cancer 26:127-132(1980)

2.PubMed=12645650; DOI=10.1016/S0165-4608(02)00657-X
Nathalie Wong, Angela Bik-Yu Hui, Bo-Li Fan, Kwok-Wai Lo, Elizabeth Pang, Sing-Fai Leung, Dolly Wai-Sen Huang Poon, Philip James Johnson;
Molecular cytogenetic characterization of nasopharyngeal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping.
Cancer Genet. Cytogenet. 140:124-132(2003)

3.PubMed=18196576; DOI=10.1002/ijc.23374
Sylvia Yat-Yee Chan, Kwong-Wai Choy, George Sai-Wah Tsao, Qian Tao, Tao Tang, Grace Tin-Yun Chung, Kwok-Wai Lo;
Authentication of nasopharyngeal carcinoma tumor lines.
Int. J. Cancer 122:2169-2171(2008)

4.PubMed=39905741; DOI=10.1002/cam4.70422; PMCID=PMC11794828
Anna Makowska, H. Udo Kontny, Josef van Helden, Barbara Hildebrandt, Herdit M. Schuler, Ralf Weiskirchen;
Genetic characterization of the immortalized human nasopharyngeal carcinoma cell line NPC/HK1.
Cancer Med. 14:e70422.1-e70422.8(2025)