大鼠耳蜗小胶质细胞系(Mocha)

背景介绍/context：

Mocha cells are a rat cochlear microglial cell line. They were developed from an immunomagnetically enriched population of CD11b+ cells from P3 rat cochlea and Immortalised with the 12S E1A gene of adenovirus in a replication-incompetent retroviral vector.Microglia are a unique lineage of mononuclear phagocytic cells that play an essential role in development, immunological defense and in- flammatory processes in the central nervous system. Microglia account for 10-15% of all cells found within the brain. As the resident macrophage cells, they act as the first and main form of active immune defence in the central nervous system (CNS).

Mocha细胞是一种大鼠耳蜗小胶质细胞系。它们是由P3大鼠耳蜗中免疫磁性富集的CD11b+细胞培养而来，并在一种不具备复制能力的逆转录病毒载体中以腺病毒的12S E1A基因永生。小胶质细胞是一种独特的单核吞噬细胞谱系，在中枢神经系统的发育、免疫防御和燃烧过程中发挥重要作用。小胶质细胞占脑内所有细胞的10-15%。巨噬细胞作为体内的巨噬细胞，在中枢神经系统(CNS)中是第一种也是主要的主动免疫防御形式。

动物种别/Organism  大鼠

组织来源 Tissue and Cell Type 耳蜗小胶质细胞

形态/Morphology 贴壁生长 

注意事项：此产品仅供科研使用