小鼠SV40永生化肝窦内皮细胞系

背景介绍/context：

Hepatic sinusoidal endothelial cells (HSECs) are an unique sub-population of liver that lines the hepatic sinusoids. Their role involves in clearing waste products from the blood, regulating pericyte contractility and innate immune functions. The Immortalised Mouse Hepatic Sinusoidal Endothelial Cells- SV40 is derived from C57BL/6 mouse HSECs that have maintained endothelial characteristics and HSEC-specific features such as vWF and caveolin-1. These cells also migrate in response to angiogenici growth factors, form vascular tube-like structures, endycytose acetylated low-density lipoprotein (AcLDL) and secrete proteins involved in matrix remodelling. In addition, these cells are easily transduced by retrovirus. The Immortalised Mouse Hepatic Sinusoidal Endothelial Cells- SV40 is therefore suitable for studying liver endothelial cell biology, including motility and angiogenesis.

肝窦内皮细胞(HSECs)是排列在肝窦内的一种独特的肝脏亚群。它们的作用包括清除血液中的废物，调节周细胞收缩能力和先天免疫功能。小鼠肝窦内皮细胞- SV40来源于C57BL/6小鼠HSECs，这些HSECs维持了内皮细胞特征和HSECs特异性特征，如vWF和caveolin-1。这些细胞还会响应血管原性生长因子而迁移，形成血管管样结构，乙酰化低密度脂蛋白(AcLDL)并分泌参与基质重构的蛋白。此外，这些细胞容易被逆转录病毒转导。因此，小鼠肝窦内皮细胞- SV40适于研究肝脏内皮细胞生物学，包括运动性和血管生成。

动物种别/Organism  小鼠

组织来源 Tissue and Cell Type 肝窦内皮细胞

形态/Morphology 内皮细胞样，贴壁生长 

注意事项：此产品仅供科研使用