MCF7 [MCF-7]人乳腺癌细胞

此细胞取材于69岁女性，MCF-7细胞保留了多个分化了的乳腺上皮的特性，包括：能通过胞质雌激素受体加工雌二醇并能形成圆形复合物（domes）。 该细胞含有Tx-4癌基因。 肿瘤坏死因子α（TNF alpha）可以抑制MCF-7细胞的生长。 抗雌激素处理细胞能调变IGFBP’S的分泌。

组织来源/Tissue and Cell Type: 腺癌，乳腺，胸水。

形态/Morphology: 上皮细胞样，贴壁生长

培养基和添加剂/Complete Growth Medium and Culture Conditions:

90%DMEM(MD0100)+10%胎牛血清(SD0200)+G/A (SD0038)

完全培养基：DMEM完全培养基（货号：MD0120）

气相：空气，95%；二氧化碳，5%。 温度：37摄氏度。

冻存条件：基础培养基+5%DMSO+20%FBS

完全冻存液：免程序降温细胞冻存液（低血清）(SD0001)

注意事项：此产品仅供科研使用

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PubMed=23671654; DOI=10.1371/journal.pone.0063056

Lu Y., Soong T.D., Elemento O.

A novel approach for characterizing microsatellite instability in cancer cells.

PLoS ONE 8:E63056-E63056(2013)

PubMed=23770244; DOI=10.1016/j.celrep.2013.05.024

Wierer M., Verde G., Pisano P., Molina H., Font-Mateu J., Di Croce L., Beato M.

PLK1 signaling in breast cancer cells cooperates with estrogen receptor-dependent gene transcription.

Cell Rep. 3:2021-2032(2013)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342

Abaan O.D., Polley E.C., Davis S.R., Zhu Y.J., Bilke S., Walker R.L., Pineda M., Gindin Y., Jiang Y., Reinhold W.C., Holbeck S.L., Simon R.M., Doroshow J.H., Pommier Y., Meltzer P.S.

The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.

Cancer Res. 73:4372-4382(2013)

PubMed=23868472; DOI=10.1038/ncomms3175

Johansson H.J., Sanchez B.C., Mundt F., Forshed J., Kovacs A., Panizza E., Hultin-Rosenberg L., Lundgren B., Martens U., Mathe G., Yakhini Z., Helou K., Krawiec K., Kanter L., Hjerpe A., Stal O., Linderholm B.K., Lehtio J.

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.

Nat. Commun. 4:2175-2175(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018

Moghaddas Gholami A., Hahne H., Wu Z., Auer F.J., Meng C., Wilhelm M., Kuster B.

Global proteome analysis of the NCI-60 cell line panel.

Cell Rep. 4:609-620(2013)

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Liu X., Nie H., Zhang Y.-B., Yao Y.-F., Maitikabili A., Qu Y.-P., Shi S.-L., Chen C.-Y., Li Y.

Cell surface-specific N-glycan profiling in breast cancer.

PLoS ONE 8:E72704-E72704(2013)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020

Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A., Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K., McCormick F., Gray J.W.

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.

Cancer Cell 24:450-465(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3

Prat A., Karginova O., Parker J.S., Fan C., He X., Bixby L., Harrell J.C., Roman E., Adamo B., Troester M., Perou C.M.

Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.

Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110

Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.

Modeling precision treatment of breast cancer.

Genome Biol. 14:R110.1-R110.14(2013)

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Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R., Hirshfield K.M., Oltvai Z.N., Vazquez A.

The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.

Cancer Metab. 1:20-20(2013)

PubMed=24618588; DOI=10.1371/journal.pone.0091433

Chernobrovkin A.L., Zubarev R.A.

Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.

PLoS ONE 9:E91433-E91433(2014)

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Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.

High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.

PLoS ONE 9:E92047-E92047(2014)

PubMed=25321415; DOI=10.1210/me.2014-1229

Li Y., Arao Y., Hall J.M., Burkett S., Liu L., Gerrish K., Cavailles V., Korach K.S.

Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant.

Mol. Endocrinol. 28:2072-2081(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

OncoImmunology 3:E954893-E954893(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35

Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)

PubMed=25807930; DOI=10.1002/anie.201500342

Broncel M., Serwa R.A., Ciepla P., Krause E., Dallman M.J., Magee A.I., Tate E.W.

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

Angew. Chem. Int. Ed. 54:5948-5951(2015)

PubMed=25828948; DOI=10.1093/jnci/djv073

Lee A.V., Oesterreich S., Davidson N.E.

MCF-7 cells -- changing the course of breast cancer research and care for 45 years.

J. Natl. Cancer Inst. 107:djv073.1-djv073.4(2015)

PubMed=26026074

Comsa S., Cimpean A.M., Raica M.

The story of MCF-7 breast cancer cell line: 40 years of experience in research.

Anticancer Res. 35:3147-3154(2015)

PubMed=26055192; DOI=10.1021/acs.jproteome.5b00375

Cifani P., Kirik U., Waldemarson S., James P.

Molecular portrait of breast-cancer-derived cell lines reveals poor similarity with tumors.

J. Proteome Res. 14:2819-2827(2015)

PubMed=26116361; DOI=10.1158/1535-7163.MCT-15-0143

Ribas R., Pancholi S., Guest S.K., Marangoni E., Gao Q., Thuleau A., Simigdala N., Polanska U.M., Campbell H., Rani A., Liccardi G., Johnston S.R.D., Davies B.R., Dowsett M., Martin L.-A.

AKT antagonist AZD5363 influences estrogen receptor function in endocrine-resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo.

Mol. Cancer Ther. 14:2035-2048(2015)

PubMed=26330541; DOI=10.1074/mcp.M115.050484

Wu X., Zahari M.S., Renuse S., Nirujogi R.S., Kim M.-S., Manda S.S., Stearns V., Gabrielson E., Sukumar S., Pandey A.

Phosphoproteomic analysis identifies focal adhesion kinase 2 (FAK2) as a potential therapeutic target for tamoxifen resistance in breast cancer.

Mol. Cell. Proteomics 14:2887-2900(2015)

PubMed=27331101; DOI=10.1016/j.dib.2016.05.040

Aumsuwan P., Khan S.I., Khan I.A., Walker L.A., Dasmahapatra A.K.

Gene expression profiling and pathway analysis data in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin.

Data Brief 8:272-279(2016)

PubMed=27362937; DOI=10.1371/journal.pone.0157290

Carrier M., Joint M., Lutzing R., Page A., Rochette-Egly C.

Phosphoproteome and transcriptome of RA-responsive and RA-resistant breast cancer cell lines.

PLoS ONE 11:E0157290-E0157290(2016)

PubMed=27377824; DOI=10.1038/sdata.2016.52