人羊膜上皮细胞（ HAEpiC ）

人羊膜由上皮细胞层、基底膜和无血管基质组成。羊膜上皮细胞（AEC）在受精后第8天由外胚层形成。AEC可能是胚胎起源的结果，缺乏主要的组织相容性复合抗原，已被用于同种异体移植治疗溶酶体疾病。研究表明，AEC具有乙酰胆碱和儿茶酚胺的合成和释放以及DA受体和DA转运体mRNA的表达等多种功能。它们表达神经元和胶质细胞标记，产生碱性成纤维细胞生长因子和肝细胞生长因子，并转化生长因子β。人AEC被认为是研究DA释放和摄取过程、受体信号转导和探索新开发的药物的合适的人类细胞模型受体。血液病从阿克森研究实验室分离出人羊膜。血液在第一道通道被冷冻保存并冷冻运送。每小瓶1毫升容量中含有>5×10^5个细胞。血液病的特征是免疫荧光法检测细胞角蛋白-18、-19和波形蛋白抗体。细胞经HIV-1，HBV，HCV，支原体，细菌，酵母和真菌检测，阴性。在AcceGen研究实验室提供的条件下，HAEpiC可达15倍增

Human amniotic membrane is composed of an epithelial cell layer, a basement membrane and an avascular matrix. The amniotic epithelial cells (AEC) are formed from epiblasts on the 8th day after fertilization. A probable result of their embryonic origin, AEC lack major histocompatibility complex antigens and have been used for allotranplantation to treat patients with lysosomal diseases. Studies have shown that AEC have multiple functions such as synthesis and release of acetylcholine and catecholamine as well as expressing mRNA coding for DA receptors and DA transporters. They express neuronal and glial cell marks, produce basic fibroblast growth factors and hepatocyte growth factors and transform growth factor-beta. Human AEC has been suggested as an appropriate human cell model for studying DA release and uptake processes, receptor signal transduction and exploring newly developed drugs acting at these receptors.HAEpiC from AcceGen Research Laboratories are isolated from human amniotic membranes. HAEpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HAEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HAEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAEpiC are guaranteed to further expand for 15 population doublings in the condition provided by AcceGen Research Laboratories.

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